"Look Mickey" features the first use of the ben-day dots borrowed from comics printed on pulp paper for which Lichtenstein is probably best known for. It is his first foray into pop-art, and thus represents a milestone not only in his career but in art history as a whole.
According to the popular lore, Lichtenstein painted "Look Mickey" after he was chided by one of his young sons. The younger Lichtenstein held up one of his comic books, and jokingly inquired if his art professor father (Lichtenstein was 37 years old at the time)would be capable of recreating the image of the Disney characters Donald Duck and Mickey Mouse on the page.
The elder Lichtenstein was evidently up to the challenge, although he did re-frame and alter the source image from the comic book in a few significant ways. For starters, he removed the visual elements from the background. Lichtenstein also flipped the POV around a full 90 degrees and simplified the features and color scheme, opting for solid blocks of primary colors that are delineated by bold black lines.
At first the art world didn't know what to make of Roy Lichtenstein and pop art in general. The two well regarded expressionists Robert Motherwell and Mark Rothko even boycotted the prestigious Sidney Janis gallery after Janis put on a Pop Art show at the gallery in 1962. The main thrust of the rebuke of pop art at the time was that artists like Lichtenstein were counterfeit artists.
It would appear, however, that there is incredible depth in "Look Mickey" and the other paintings which comprise the cannon of pop art in the 1960s. These days, it appears that more pages of art criticism is dedicated to Lichtenstein and the pop art movement than any other due to the aesthetic and philosophical implications of the movement. Scholars are still trying to unpack the deep sense of humor in "Look Mickey" and other examples of early pop art.